Genocea Biosciences Inc (GNCAQ)

[jondoeuk]

''NT-125 is an investigational, autologous, fully-individualized, multi-specific TCR therapy targeting neoantigens for the treatment of advanced solid tumors. NT-125 is designed to contain up to five distinct neoantigen-specific TCRs per patient in a single cell product of highly functional engineered T cells, allowing multiple neoantigens presented by HLA class I and HLA class II molecules to be targeted with the goal to create a more impactful TCR therapy for more patients. NT-125 aims to reduce the probability of antigen escape and potentially maximize the depth and durability of clinical responses in a patient population with difficult to treat tumors and high unmet need.'' https://www.biospace.com/article/releases/neogene-therapeutics-announces-approval-of-clinical-trial-application-for-its-first-phase-1-trial-of-novel-fully-individualized-tcr-therapy-to-treat-advanced-solid-tumors/

Also, https://www.businesswire.com/news/home/20220111005172/en/Neogene-Therapeutics-Announces-Exclusive-License-with-the-National-Cancer-Institute-for-a-Portfolio-of-T-Cell-Receptors-TCR-Targeting-KRAS-and-TP53-Mutations-for-the-Treatment-of-Cancer