Many DNA-editing enzymes have been used to shift heteroplasmy, but they have their pitfalls in terms of potential clinical use. MitoZFN’s and mitoTALENs have a heterodimeric architecture, making packaging into viral vectors difficult, requiring that each monomer is packaged into separate viral vectors. The CRISPR-Cas9 system is not appropriate for mtDNA modification, because mitochondria do not have an RNA import mechanism33. More recently, a base editor DdCBE was shown to edit cytosines preceded by thymidines34. However, the sequence requirements limit its potential use at this time35. It has, however, recently been used to edit mtDNA in mouse embryos36. MitoARCUS overcomes disadvantages that mitoZFN and mitoTALENs present with size and viral packaging.
Recent DTIL News
- Precision BioSciences Announces Grant of Inducement Awards Under Nasdaq Listing Rule 5635(c)(4) • Business Wire • 09/20/2024 11:01:00 AM
- Form 8-K - Current report • Edgar (US Regulatory) • 09/12/2024 12:00:13 PM
- Precision BioSciences Strengthens Senior Leadership Team Ahead of Anticipated PBGENE-HBV Clinical Execution • Business Wire • 09/12/2024 11:15:00 AM
- Precision BioSciences to Participate in Upcoming H.C. Wainwright 26th Annual Global Healthcare Conference • Business Wire • 09/04/2024 11:01:00 AM
- Form 8-K - Current report • Edgar (US Regulatory) • 09/03/2024 12:03:28 PM
- Precision BioSciences Receives $13 Million in Proceeds from Imugene Convertible Note Maturity as Part of the August 2023 Azer-cel Deal • Business Wire • 09/03/2024 11:01:00 AM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 08/23/2024 11:30:06 AM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 08/23/2024 11:30:05 AM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 08/23/2024 11:30:04 AM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 08/23/2024 11:30:02 AM
- Precision BioSciences Announces Investigational New Drug Clearance by Partner TG Therapeutics for Investigation of Azer-Cel for Multiple Sclerosis • Business Wire • 08/09/2024 11:01:00 AM
- Form 10-Q - Quarterly report [Sections 13 or 15(d)] • Edgar (US Regulatory) • 08/01/2024 11:30:25 AM
- Form 8-K - Current report • Edgar (US Regulatory) • 08/01/2024 11:30:08 AM
- Precision BioSciences Reports Second Quarter 2024 Financial Results and Provides Business Update • Business Wire • 08/01/2024 11:15:00 AM
- Precision BioSciences to Participate in Upcoming August Investor Conferences • Business Wire • 07/31/2024 11:01:00 AM
- Precision BioSciences to Report Second Quarter Results on August 1, 2024 • Business Wire • 07/29/2024 08:15:00 PM
- Precision BioSciences to Present at the Upcoming JonesTrading Healthcare Seaside Summit • Business Wire • 07/08/2024 11:01:00 AM
- Precision BioSciences Announces its Addition to the Russell Microcap® Index • Business Wire • 07/01/2024 11:01:00 AM
- Precision BioSciences Announces Presentation at UMDF Mitochondrial Medicine 2024 Supporting Advancement of PBGENE-PMM Program Towards IND and/or CTA in 2025 • Business Wire • 06/27/2024 11:01:00 AM
- Precision BioSciences Expands Hepatitis Scientific Advisory Board with Addition of World-Class Clinical Investigators Mark Sulkowski, M.D. and Jordan Feld, M.D., MPH, as PBGENE-HBV Program Nears Clinical Readiness • Business Wire • 06/20/2024 11:00:00 AM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 06/11/2024 09:13:30 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 06/11/2024 09:13:07 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 06/11/2024 09:12:35 PM
- Form 144 - Report of proposed sale of securities • Edgar (US Regulatory) • 06/10/2024 07:15:20 PM
- Form 144 - Report of proposed sale of securities • Edgar (US Regulatory) • 06/10/2024 07:12:02 PM
Lingerie Fighting Championships Signs Broadcast Deal With Maybacks Global Entertainment • BOTY • Sep 26, 2024 9:00 AM
Maybacks Global Entertainment and Lingerie Fighting Championships Enter Into Broadcast And Revenue Sharing Agreement • AHRO • Sep 26, 2024 8:30 AM
North Bay Resources Commences Operations at Bishop Gold Mill, Inyo County, California; Engages Sabean Group Management Consulting • NBRI • Sep 25, 2024 9:15 AM
CEO David B. Dorwart Anticipates a Bright Future at Good Gaming Inc. Through His Most Recent Shareholder Update • GMER • Sep 25, 2024 8:30 AM
Cannabix Technologies and Omega Laboratories Inc. Advance Marijuana Breathalyzer Technology - Dr. Bruce Goldberger to Present at Society of Forensic Toxicologists Conference • BLOZF • Sep 24, 2024 8:50 AM
Integrated Ventures, Inc Announces Strategic Partnership For GLP-1 (Semaglutide) Procurement Through MedWell USA, LLC. • INTV • Sep 24, 2024 8:45 AM