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NY1972

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NY1972

Re: NY1972 post# 886

Saturday, 04/23/2022 10:05:37 PM

Saturday, April 23, 2022 10:05:37 PM

Post# of 932
The reason high-dose cyclophosphamide is able to ablate the effector cells without destroying hematopoietic stem cells is that the earliest stem cells (but not lymphocytes) contain high levels of aldehyde dehydrogenase conferring resistance to the cytoxic properties of cyclophosphamide. Dr. Brodsky and his colleagues in neurology and rheumatology are applying this approach in other severe autoimmune disorders including, scleroderma, myasthenia gravis, multiple sclerosis and autoimmune hematologic disorders.

https://ashpublications.org/blood/article/115/11/2136/27022/High-dose-cyclophosphamide-for-severe-aplastic
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