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The amino acid glycine has a hyperpolarizing effect on airway smooth muscle that is bronchodilatory. Insuring optimal intracellular levels of magnesium may modestly blunt the stimulatory impact of intracellular free calcium on bronchoconstriction. Nutraceutical regimens or functional foods incorporating at least several of these agents may have utility as nutraceutical adjuvants to standard clinical management of asthma.
https://www.dovepress.com/review--nutraceuticals-can-target-asthmatic-bronchoconstriction-nadph--peer-reviewed-fulltext-article-JAA
Glycine complements NAC in raising glutathione tissue levels
https://www.nutraingredients.com/Article/2021/06/28/Review-assesses-nutraceutical-measures-for-asthma-relief
Supplementation with GlyNAC (combination of glycine and N-acetylcysteine as a cysteine precursor) was found to improve/correct cellular glycine, cysteine, and GSH deficiencies; lower OxS; and improve mitochondrial function, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, and multiple aging hallmarks; and improve muscle strength, exercise capacity, cognition, and body composition.
https://pubmed.ncbi.nlm.nih.gov/34587244/
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