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Tuesday, February 22, 2022 9:53:51 AM
"The NASH trial achieved the primary endpoint of proton density fat fraction (PDFF) and the secondary endpoint of cT1. PDFF is an MRI-derived biomarker for fatty deposition, while cT1 is an iron-corrected T1 mapping indicator of fibrosis and liver inflammation. Both endpoints were used to assess the NASH risk.
Participants were given leronlimab weekly during the two-part NASH trial. Part I observed a weekly dose of 700 mg versus a placebo in double-blind and randomized setting. Part II looked into a weekly dose of 350 mg versus placebo in an open label study. Topline results are expected to be announced soon. The researchers found a statistically significant improvement in the 350 mg dose group for both the primary and secondary endpoints. "
LL NASH 350 mg was mediocre and is not competitive with the leading NASH competitors
My comments are just my opinions and should NOT be taken as investment advice.
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