Oncology Pharma Inc (ONPH)

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Oncology Pharma Gives Update on Technology, Formulation and Data Creation
February 08 2022 - 06:30AM
InvestorsHub NewsWire
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SAN FRANCISCO, CA – February 8, 2022 – InvestorsHub NewsWire -- Oncology Pharma Inc. (OTC PINK: ONPH) - Oncology Pharma, Inc. ("The Company") is pleased to announce that the co-development agreement and ongoing work to advance the licensed technology with Nanosmart has identified that the formulations demonstrate the time-release characteristic that is expected to improve the safety and localization profile of the eventual lead candidate formulation(s). Data provided below:

Initial Formulations
Tested for drug incorporation (visual): > 95% drug incorporation.
50% remaining after 3 hours (better than free-drug formulation).
Formulation had aggregation after several days in 4oC storage.



Series A-1 Formulation
Tested for drug incorporation (spectrophotometer – quantitative measurement) – 100% drug incorporated.
However, formulation had aggregation after several days in 4oC storage.



Series A-2 Formulation
Preparation showed aggregation overnight at 4oC, could not be filtered through 0.22 um membrane filter.
Decided to switch to natural vs. hydrogenated oil to increase amount of drug incorporation and to reduce aggregation (natural oil appears to aggregate less than hydrogenated in storage).
Series B-1 Formulation (natural oil)
Attempted to filter through 0.22 um filter. Filter clogged quickly, indicating significant aggregation after formulation (prior to storage).



Series B-2 Formulation
Dilution and minor change to B-1 formulation change and extrude 10X.
Showed 100% incorporation of drug (visual).
Still visible aggregation upon storage at 4oC (approx. 50%) – still possible to filter through a 0.22 um filter.
Upon additional research, appears that repeated extrusion may impart additional energy to nanoemulsion causing nanodroplets to aggregate. In addition, an ice bath was not used during this prep which may be a factor.



Series B-3 Formulation
B-2 formulation was extruded 3x through 400/200/100 nm membranes at room temperature.
B-3 formulation was possible to filter trough 0.22 um filter without clogging (see picture next slide).
Increasing amount of glycerol added to B-3 formulation did not improve formulation.
Drug release study conducted at 37oC:
70% remaining after 1 hour, 35% remaining after 3 hours, 5% remaining after 6 hours. Improving upon this is desirable, but this is workable as a time-release formulation.
Submitting split samples for physical characterization and initial analytical method validation.

The proprietary nanoemulsion being developed also has the novel potential to be stable during storage for an extended period of time. This is in contrast to most lipid nanoparticle formulations that typically have a very short shelf-life once formulated. The nanoemulsion formulation can likely be utilized for a broad range of cancer drugs that are lipophilic (i.e., not water soluble), thus expanding the potential to license additional drug formulations utilizing this same platform technology, with each novel drug being safer and more effective than the predicate drug formulation currently on the market.

Advancement continues to be made on the feasibility testing and initial gathering of data of nanoemulsion formulations for dactinomycin. Early work continues to be promising with formulations demonstrating a satisfactory level of nanoemulsion loading and retention of dactinomycin. Studies to assess the physical characterization of the formulations, as well as quantitative performance measures (e.g., storage stability, time-to-release, etc.) are underway.



ABOUT ONCOLOGY PHARMA, INC.

ONCOLOGY PHARMA, INC. (OTC PINK:ONPH) (the 'Company') is currently engaging in research and development of therapeutics for oncology and prides itself for having a world-class Advisory Board that keeps the Company in the forefront of developing technologies in cancer research, biotechnology, and healthcare.



ABOUT NANOSMART PHARMACEUTICALS, INC.

NanoSmart® Pharmaceuticals is a privately-held California corporation that is developing nanoparticle drug delivery platforms, including utilization of anti-nuclear antibody (ANA) to enable targeted drug delivery of existing drug therapies to areas of necrosis present in virtually all solid cancer tumors.

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