Medical World News

[Preciouslife1]

A related factor that has to be considered is antibody-dependent enhancement of infection (ADE) by vaccines. This is best known with dengue, RSV and measles vaccines. It occurs when non-neutralizing antibodies actually facilitate attachment of wild viruses to cells, thereby producing more severe illness in vaccinated individuals than in unvaccinated individuals. Iwasaki and Yang suggested that this is a potential danger with Covid-19 vaccines. (Nat Rev Immunol 2020;20:339) It may, therefore, be of vital importance that Yahi and colleagues have shown that vaccines directed against the original Wuhan/D614G strain produce antibodies that fail to neutralize Delta variants and allow the attachment of Delta viruses to cells. (Yahi et al, Journal of Infection 2021;16:58, August 16) Some of the breakthrough illnesses caused by the Delta variant in vaccinated individuals may be the result of this interaction.

https://www.bmj.com/content/374/bmj.n2029/rr