InvestorsHub Logo
Followers 65
Posts 2029
Boards Moderated 0
Alias Born 10/31/2017

Re: None

Sunday, 12/26/2021 10:14:22 AM

Sunday, December 26, 2021 10:14:22 AM

Post# of 302
Preclinical Gene Editing Data on its ARCUS-Based Chronic Hepatitis B Program at the HEP DART 2021 Conference

In this preclinical study, ARCUS efficiently targeted and degraded HBV cccDNA and reduced expression of HBV s-antigen (HBsAg) by 77% in HBV-infected primary human hepatocytes. To evaluate ARCUS in vivo, mouse and non-human primate models were developed that utilized an episomal adeno-associated virus (AAV) containing a portion of the HBV genome to serve as a surrogate for cccDNA. In both episomal models, a robust decrease in AAV copy number and high on-target editing in remaining AAV was observed, and a durable 96% reduction of HBsAg was further observed in mice.

See page 37 for abstract.

https://static1.squarespace.com/static/5c912d7af8135a45d18dd805/t/61aa80a73f24a36f20f71eca/1638564010806/hepdart-2021-abstract-book-final%5B26%5D.pdf
Volume:
Day Range:
Bid:
Ask:
Last Trade Time:
Total Trades:
  • 1D
  • 1M
  • 3M
  • 6M
  • 1Y
  • 5Y
Recent DTIL News