I’ve heard that this has been a problem known to the vial manufacturer(s) for a while. Apparently, the pH > 10 (I’m amazed that isn’t ‘uncomfortable’) in some injectables. In those very alkaline solutions the glass, unsurprisingly, reacts and forms clay particles that eventually are large enough and of sufficient quantity to be visible. Apparently, the Mg-bearing borosilicate glasses are particularly prone.
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