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Thursday, December 09, 2021 5:44:48 PM
GSK's GSK3845097 (one of three next-gen versions they both worked on together*), which co-expresses a dominant-negative TGF-ß type II receptor and targets NY-ESO-1 is in the clinic.
* So is another, the CD4+ T-cells co-express a CD8 co-receptor (again, it targets NY-ESO-1). The third isn't in the clinic, but it could overexpress PDE7A (increases resistance to both PGE2/adenosine and enhances apoptosis in target cells).
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