Innovation Pharmaceuticals Inc (IPIX)

[farrell90]

The Wang paper and the Bakovic paper are not equivalent studies and should not be directly compared.

The Wang study was on 3 coronaviruses associated with the common cold as it outlines in the first paragraph.It also studied an HIV hybrid with a Sars2 spike protein. It did not study a cornavirus associated with Covid 19.

"Human coronavirus (HCoV)-229E, -NL63, -OC43 and -HKU1 account for 15~30% cases of common cold worldwide"

https://www.biorxiv.org/content/10.1101/2021.11.04.467344v1.full

The Wang paper did not study the chronaviruses associated with Covid 19 where the Bakovic paper studied viruses proven to cause Covid 19.

"SARS-CoV-2 (Washington strain 2019-nCoV/USA-WA1/2020) was obtained from BEI Resources (NR-52281) and was used for all infections..."

https://www.mdpi.com/1999-4915/13/2/271/htm

The Wang paper primarily studied the affect of Brilacidin on viral attachment and viral entry into the cell. It did not study the virucidal effects of Brilacidin as outlined in the Bakovic paper and as such the IC 50 in the Wang paper and the Bakovic paper should not be directly compared

The Wang paper is very important because it delineates how Brilacidin has 2 mechanisms of action in blocking viral entry to the cell by attaching to the host receptor as well as the virus.It also shows it binds to the heparin sulfate proteoglycans and not the spike protein like the monoclonal antibody treatments.

The covid 19 mutations described in the data to date affect the spike protein. Since Brilaidins activity is independent of spike protein mutation, it means Brilacidin is less likely to develop resistance to treatment.

The Bakovic study, both in Vero and human Calu-3 Cells, did assays which included both the virucidal MOA as well as blocking viral entry and discovered the low IC 50 and high Selectivity index. The Wang study of the virucidal effect is done in a way which would not be comparable.

The 2 studies should be looked on as being complementary rather than contradictory. Both studies confirm and further define the activity of Brilacidin against different species of cornavirus


The above is from my review of both studies. I am not a virologist and I look forward to informed comments.

GLTA,

Farrell