CytoSorbents Corporation (CTSO)

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Successful Treatment of Severe Lamotrigine Intoxication with CytoSorb Hemoadsorption
Reuchsel C & Gonnert FA. Blood Purif 2021; epub
11/2021
In this case report a deeply comatose 60 yr old woman was treated in intensive care for severe lamotrigine intoxication for which there is no antidote. As other conventional therapeutic measures including lipid infusion failed to have any effect on the lamotrigine levels, a CytoSorb adsorber was started on day 8, together with continuous veno-venous hemodialysis, and continued for 44 hours (3 adsorbers used). Within the first 24 hrs of CytoSorb use the patient began to try to open her eyes to command. This was accompanied by a rapid and sustained decrease in lamotrigine plasma concentrations and concomitant further clinical improvement in regard to vigilance. The patient was able to be discharged two days after CytoSorb cessation. The authors conclude that comparison of pre- and post-adsorber levels suggested the direct adsorption of the drug by the adsorber and state that its use could represent a viable treatment option for patients with severe lamotrigine intoxication.