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Thursday, November 18, 2021 11:04:43 AM
"Antibody-drug conjugates (ADCs) are targeted immunotherapies that utilize potent cytotoxic drugs conjugated to antibodies via chemical linkers. This increases the efficacy of chemotherapeutic agents by effectively targeting the drug directly to cancer cells. Thus, ADCs also have reduced side effects because targeting the cancer cells means less of the cytotoxic drug will enter healthy cells.
Sorrento’s next generation ADC technology platform utilizes innovative conjugation methods to produce stable ADCs by linking the toxin to only specific, preselected sites of an antibody; the resulting ADCs have shown high anti-tumor efficacy in preclinical studies." Sorrento has mentioned ...
CD38 ADC
Trop2 ADC
BCMA ADC
and half a dozen Mayo Clinic ADNAB ADCs. Some are in phase 1 and some ADNAB are in phase 2.
"The refusal of the real is the number one dogma of our time" Rene Girard
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