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Sunday, November 07, 2021 9:37:42 AM
Researchers found that the genetic signal is likely to affect cells in the lung. By finely examining DNA at the site of the genetic signal (LZTFL1 gene) controlled by the so-called 'switch', they identified the gene responsible for the greater risk of developing severe COVID-19.
News > Medscape News UK
Gene Identified for High Risk of COVID Mortality Much More Common in South Asians
Becky McCall
November 05, 2021
1
A gene that doubles the risk of respiratory failure and death from COVID-19, and is present in 60% of South Asians, but only 15% of Europeans, has been identified and might explain the excess deaths in some ethnic groups over others.
Researchers from Oxford University led by James Davies, consultant in intensive care medicine and associate professor of genomics, and Jim Hughes, PhD, professor of gene regulation, both at the University of Oxford's MRC Weatherall Institute of Molecular Medicine, used an artificial intelligence algorithm to analyse huge quantities of genetic data from hundreds of types of cells, to show that the gene, leucine zipper transcription factor-like 1 (LZTFL1), is associated with lung function rather than the immune system. The study findings are published in Nature Genetics.
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