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Thursday, November 04, 2021 6:07:16 PM
"Innovation Pharmaceuticals announces results of Phase II study of brilacidin in COVID-19
Analysis of the top lines results of this 120 patient study of brilacidin plus Standard of Care versus placebo and Standard of Care has now been completed.
Encouragingly, brilacidin proved effective in a number of patients hospitalized with COVID-19. However these results failed to reach statistical significance.
This failure to reach significance was due to a more robust and pronounced effect in the placebo group than was anticipated, and therefore the study was not sufficiently powered to produce a statistically significant result. Additionally the requirement to use a lower dose of brilacidin than that used in previous Phase II studies resulted in lower serum levels than perhaps were necessary for efficacy.
However retrospective analyses of some patient sub-sets have revealed some promising and encouraging directions for future research. For example, people between the age of 60 and 62 in the two US centers did better on brilacidin than on placebo**.
Investigation of these promising avenues will require a Phase IIB clinical trial program and we are in the process of discussions with various entities regarding funding for this program."
* For clarity's sake, this is not a fake, counterfeit or other PR. It's merely my prediction as to what next week's PR will roughly say.
** Or other similar targets drawn round the bullet holes on the barn door after the rifle has been fired.
"Nobody ever went broke underestimating the intelligence of the
American public."
H. L. Mencken
"It’s easier to fool people than to convince them that they have been fooled."
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