Followers | 145 |
Posts | 27558 |
Boards Moderated | 3 |
Alias Born | 02/07/2004 |
Wednesday, October 27, 2021 10:39:44 AM
https://finance.yahoo.com/news/biomica-rambam-health-care-campus-121500590.html
REHOVOT and HAIFA, Israel, Oct. 27, 2021 /PRNewswire/ -- Biomica Ltd., an emerging biopharmaceutical company developing innovative microbiome-based therapeutics and a subsidiary of Evogene Ltd. (NASDAQ: EVGN) (TASE: EVGN), and Rambam Health Care Campus today announced the signing of a clinical trial agreement (CTA) for initiating a first in-human proof-of-concept (POC) for BMC128, Biomica's drug candidate.
The study is titled, "A Phase 1, Open-Label Study to Evaluate the Safety and Tolerability of BMC128 in Combination with anti-PD-1 in Patients with Non-small Cell Lung Cancer (NSCLC), Melanoma or Renal Cell Carcinoma (RCC)." The study is designed primarily to evaluate the safety and tolerability of Biomica's microbiome-based immuno-oncology drug candidate, BMC128, in combination with immune checkpoint inhibitor (ICI) immunotherapy (an anti PD-1 agent).
The initiation of this study is pending approval by the Israeli Ministry of Health (MoH).
Dr. Elran Haber, CEO of Biomica, stated: "We are very excited to work with one of Israel's leading healthcare institutions, the Rambam Health Care Campus, and we look forward to initiating our first in-human POC study for BMC128, for the treatment of refractory cancer patients. Based on the compelling preclinical results achieved to-date, we are thrilled to take this next step in advancing BMC128 through the clinical development process. We hope that this important collaboration will be followed by further partnerships with additional leading medical institutions."
Dr. Ruth Perets, Head of Rambam's Oncology Phase 1 Clinical Trials, stated: "We are thrilled to lead this clinical trial, aiming to target the important issue of ICI resistance. ICIs have revolutionized the field of oncology, providing prolonged survival in many malignancies. However, resistance to ICI eventually occurs in most patients, and evidence suggests that the gut microbiota plays a role in ICI resistance. We are excited to the test the ability of BMC128 to overcome ICI resistance and help provide patients meaningful and long responses to treatment."
As previously reported, treatment with BMC128 in combination with ICI immunotherapy, significantly enhanced anti-tumor activity in various preclinical models. This resulted in an increased response of tumors to anti-PD1, as demonstrated in an improved Objective Response Rate (ORR) and Percent Tumor Growth Inhibition (%TGI). Response to BMC128 was correlated with a desired anti-tumor immunological profile. BMC128 changed the course of response to ICI, leading to stimulation of the immune system which shifted cold-tumors into hot-tumors.
Biomica's immuno-oncology program is based on the premise that the gut microbiome affects the efficacy of cancer immunotherapy, specifically that of the ICI involving the blockade of PD-1 or PD-L1 and CTLA-4 as suggested in scientific literature[1],[2]. Fecal microbial transplantation has been recently reported to increase response in patients resistant to immune-checkpoint therapy[3],[4]. However, the specific microbial entities driving this response are currently unknown.
BMC128 is a rationally designed microbial consortium identified and selected through a detailed functional microbiome analysis using PRISM, a proprietary high-resolution microbiome analysis platform powered by Evogene's MicroBoost AI platform.
About BMC128:
Developed as a Live Bacterial Product (LBP), BMC128 is a rationally-designed LBP consortium comprised of four unique bacterial strains, natural inhabitants of the human intestinal tract, that harbor specific functional capabilities with the potential to enhance immunological therapeutic responses and facilitate anti-tumor immune activity through multiple biological processes.
Rationally-designed consortia are multi-strain products designed to restore diversity and specific functionality to a host's microbial community with individually selected, cultured bacteria.
Recent EVGN News
- Biomica to Present at the American Society of Clinical Oncology (ASCO) 2024 Annual Meeting • PR Newswire (US) • 04/16/2024 11:00:00 AM
- Biomica to Present at Digestive Disease Week (DDW) Conference 2024 Annual Meeting • PR Newswire (US) • 04/11/2024 11:00:00 AM
- Evogene and The Kitchen FoodTech Hub by Strauss Group Established Finally Foods Ltd. - Revolutionizing Protein Production in Plants for the Food Industry • PR Newswire (US) • 04/02/2024 11:00:00 AM
- Evogene Announces Filing of Annual Report on Form 20-F • PR Newswire (US) • 03/28/2024 01:00:00 PM
- Evogene Reports Receipt of Nasdaq Minimum Bid Price Notification • PR Newswire (US) • 03/20/2024 01:00:00 PM
- Bayer AG and Lavie Bio Continue for Second Year of Biofungicides Validation Following Successful Lab and Greenhouse Testing • PR Newswire (US) • 03/19/2024 01:00:00 PM
- Lavie Bio and Ceres Global Ag Corp. Collaborate to Include YalosTM Bio-Inoculant, in Regenerative Agriculture Initiatives in North America • PR Newswire (US) • 03/13/2024 01:00:00 PM
- Form 6-K - Report of foreign issuer [Rules 13a-16 and 15d-16] • Edgar (US Regulatory) • 03/07/2024 12:00:17 PM
- Evogene Reports Fourth Quarter and Full Year 2023 Financial Results • PR Newswire (US) • 03/07/2024 12:00:00 PM
- AgPlenus Achieves Milestone in Collaboration with Corteva to Develop Novel Herbicides • PR Newswire (US) • 03/06/2024 12:00:00 PM
- Casterra Announces New Agreements with Seed Producers in Brazil and Africa to Meet Growing Demand for its Elite Castor Seed Varieties • PR Newswire (US) • 03/05/2024 12:00:00 PM
- Form F-3 - Registration statement by foreign private issuers • Edgar (US Regulatory) • 03/01/2024 12:03:59 PM
- Lavie Bio Successfully Secures Second Half Advance Payment of $2.5M after Meeting Corteva's Licensing Agreement Requirements • PR Newswire (US) • 02/28/2024 12:00:00 PM
- Evogene Schedules Fourth Quarter 2023 Financial Results Release & Conference Call for March 7th, 2024 • PR Newswire (US) • 02/26/2024 12:00:00 PM
- Form 6-K - Report of foreign issuer [Rules 13a-16 and 15d-16] • Edgar (US Regulatory) • 02/22/2024 12:00:08 PM
- AgPlenus Announces Appointment of Dr. Dan Jacob Gelvan as its Incoming Chief Executive Officer • PR Newswire (US) • 02/22/2024 12:00:00 PM
- Form 6-K - Report of foreign issuer [Rules 13a-16 and 15d-16] • Edgar (US Regulatory) • 02/21/2024 12:01:13 PM
- AgPlenus Announces Licensing & Collaboration Agreement with Bayer to Develop a New Sustainable Weed Control Solution • PR Newswire (US) • 02/21/2024 12:00:00 PM
- Syngenta and Lavie Bio Announce Partnership to Discover and Develop Novel Bio-Insecticide • PR Newswire (US) • 02/20/2024 12:00:00 PM
- Form SC 13G - Statement of acquisition of beneficial ownership by individuals • Edgar (US Regulatory) • 02/15/2024 01:30:01 AM
- Evogene and Verb Biotics Enter Collaboration Agreement to Advance Probiotic Innovation • PR Newswire (US) • 02/06/2024 12:08:00 PM
- Biomica CEO Set to Engage in Panel Discussion at 8th Annual European Microbiome Movement Summit • PR Newswire (US) • 01/23/2024 12:00:00 PM
- Form 6-K - Report of foreign issuer [Rules 13a-16 and 15d-16] • Edgar (US Regulatory) • 01/17/2024 12:00:06 PM
- Biomica Successfully Completes Phase I Trial Enrollment for Microbiome-Based Immuno-Oncology Drug • PR Newswire (US) • 01/17/2024 12:00:00 PM
- Form 6-K - Report of foreign issuer [Rules 13a-16 and 15d-16] • Edgar (US Regulatory) • 01/09/2024 01:30:57 PM
FEATURED Cannabix's Breath Logix Alcohol Device Delivers Positive Impact to Private Monitoring Agency in Montana, USA • Apr 25, 2024 8:52 AM
Bantec Reports an Over 50 Percent Increase in Sales and Profits in Q1 2024 from Q1 2023 • BANT • Apr 25, 2024 10:00 AM
Kona Gold Beverages, Inc. Announces Name Change to NuVibe, Inc. and Initiation of Ticker Symbol Application Process • KGKG • Apr 25, 2024 8:30 AM
Axis Technologies Group and Carbonis Forge Ahead with New Digital Carbon Credit Technology • AXTG • Apr 24, 2024 3:00 AM
North Bay Resources Announces Successful Equipment Test at Bishop Gold Mill, Inyo County, California • NBRI • Apr 23, 2024 9:41 AM
Epazz, Inc.: CryObo, Inc. solar Bitcoin operations will issue tokens • EPAZ • Apr 23, 2024 9:20 AM