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Sunday, October 17, 2021 9:27:38 AM
While working on the MERS vaccine, a different coronavirus prior to the current SARS-COV2 pandemic, a team of scientists discovered if they added two amino acids (protein building blocks) it can stabilize its spike protein into the pre-fusion conformation. This way more of the antibodies can be neutralizing.
The Moderna, Pfizer/BioNTech, Janssen (Johnson and Johnson) and Novavax vaccines contain the modified spike protein sequence that stabilizes the spike protein into the pre-fusion conformation. Scientists think that keeping the spike protein in the pre-fusion conformation may lead to more neutralizing antibodies. Time will tell whether the vaccines with the locked prefusion conformation spike protein will be more effective against SARS-CoV2 compared to the other vaccines which contain the wild-type spike protein.
https://dearpandemic.org/spike-protein-differences-between-different-vaccines/
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