Tuesday, August 31, 2021 1:14:46 AM
https://ncats.nih.gov/antivirals
Interesting some of the viruses of interest named were the ones reported in the recent GMU research of Brilacidin's antiviral effects.
In addition to SARS-CoV-2, NCATS’ activities will address other viruses within the scope of the APP that represent known threats because of their pandemic potential. The table below shows virus families/orders and examples of viruses that the APP may target.
Viral Family/Order Example Viruses
Coronaviridae SARS-CoV, MERS-CoV, SARS-CoV-2
Bunyavirales Rift Valley fever, Hantavirus, Crimean-Congo hemorrhagic fever
Filoviridae Ebola, Marburg
Flaviviridae Yellow fever, Dengue, Zika
Paramyxoviridae Hendra, Nipah
Picornaviridae Enterovirus D68
Togaviridae Chikungunya
From post 366725
Bunyavirus infections are the causative agent in a number of serious human diseases.
Pneumonitis
-Hantavirus has a mortality rate of 35%
https://www.ecdc.europa.eu/en/hantavirus-infection/facts
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840873/
Hemorrhagic fever
-Rift valley fever
https://www.cdc.gov/vhf/rvf/about.html
-Lassa fever
https://www.who.int/health-topics/lassa-fever#tab=tab_1
Severe fever with thrombocytopenia syndrome (SFTS}
https://www.nature.com/articles/s12276-021-00610-1
Encephalitis
-California and LaCross encephalitis
https://emedicine.medscape.com/article/234159-overview
-Crimea-congo encephalitis
https://www.who.int/news-room/fact-sheets/detail/crimean-congo-haemorrhagic-fever
Brilacidin is also reported to be effective in some alpha viruses.
Alpha viral diseases include Togaviridae. Virus, chickungunya; Ross River; Mayaro; , O'nyong-nyong; Sindbis; eastern equine encephalitis; Venezuelan equine encephalitis.
GLTA Farrell
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