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Thursday, August 26, 2021 4:07:33 PM
MPI8 demonstrated superior antiviral activity in a head-to-head comparison with a late-stage clinical antiviral compound (EIDD-2801).
Based on the IC50 data of the Plague Reduction Neutralization Test (PRNT) of live virus infecting Vero E6 cells, MPI8 demonstrated approximately ten-fold (10x) higher antiviral potency than EIDD-2801 against SARS-CoV-2 and its Alpha (UK) and Delta (Indian) VoCs and three to seven-fold (3-7x) higher antiviral potency against Beta (South Africa, 3X) and Gamma (Brazil/Japan, 6-7X) VoCs.
EIDD-2801 is in a phase 2/3 study by Merck. The US government is committed to purchasing $1.2 billion worth of EIDD-2801 if the current trials are successful.
If MP18 is 3-10 times more effective what will it be worth?
"The refusal of the real is the number one dogma of our time" Rene Girard
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