Innovation Pharmaceuticals Inc (IPIX)

[farrell90]

It is a great question. I have researched the old Polymedix data a number of times; and I have never found Brilacidin's blood brain barrier penetration documented.

Perhaps someone else can find it.

I did find this:

"Defensins are small, cationic, cyclic peptides that are abundantly stored in granules of neutrophils. Defensins non-specifically interact with membranes by forming weakly ion-selective pores. Here we demonstrate immunolocalization of defensin-secreting cells in human brain. Defensins, secreted by activated granulocytes, apparently are not prevented by the blood-brain barrier (BBB) from diffusing across cerebral endothelium to penetrate...

This may not apply to Brilacidin,but Brilacidin is a small, cationic definsin mimetic.

GLTA Farrell