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Re: redspinelpinktopaz post# 17766

Friday, 08/06/2021 6:57:09 PM

Friday, August 06, 2021 6:57:09 PM

Post# of 21540
AD, autism and FXS are all brain disorders caused by faulty wiring in the brain (it's actually a bit more complicated than that but you get the point). The idea is to regenerate the wiring in the brain by activating an enzyme called PKCe, which seems to be important for brain development in normal children but disappears as time goes on due to age-related damage. Bryo is their first generation PKCe activator and if they are successful they will continue development on their drug platform of next-gen PKCe activators.

Will it work? Nobody knows, but there are preclinical mouse studies showing improvements in both FXS mice and autistic mice.

It's all some form of brain damage really, and the hope is that PKCe activators are the first class of drugs to make the human brain create new connections to make up for the damaged or missing ones.

Is it a miracle drug? Of course not, but it could be the first drug that generates new synapses and creates new connections in the brain. Is that the right approach? Again, nobody knows.

Our memories and personalities are all formed by those brain cells in our head that are intervowen with each other, so it's very important that we maintain existing connections and repair damaged ones. It is after all the most important organ we have.

A beating heart won't help much if your head is gone.
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