Wednesday, August 04, 2021 10:50:09 AM
Author links open overlay panelReinVerbekeabIneLentackerabStefaan C.De Smedtab1HeleenDewitteabc1
https://doi.org/10.1016/j.nantod.2019.100766Get rights and content
Highlights
•
mRNA represents an attractive source of antigen in vaccination approaches.
•
Both unformulated and nanoparticulate mRNA are used for direct in vivo vaccination.
•
Nanoformulation widens the administration and delivery options for mRNA vaccines.
•
The self-adjuvant effect of mRNA is a double-edged sword for vaccine efficacy.
•
Rationale for combining mRNA cancer vaccines with checkpoint inhibition.
Abstract
In the early nineties, pioneering steps were taken in the use of mRNA as a therapeutic tool for vaccination. In the following decades, an improved understanding of the mRNA pharmacology, together with novel insights in immunology have positioned mRNA-based technologies as next-generation vaccines. This review outlines the history and current state-of-the-art in mRNA vaccination, while presenting an immunological view on mRNA vaccine development. As such, we highlight the challenges in vaccine design, testing and administration, key considerations in the design of mRNA-based vaccines and new opportunities that arise when packaging mRNA in nanoparticulate vaccines. Finally, we discuss the mRNA self-adjuvant effect as a critical, but dichotomous parameter that determines the safety, efficacy and strength of the evoked immune response.
Graphical abstract
Download : Download high-res image (129KB)Download : Download full-size image
https://www.sciencedirect.com/science/article/abs/pii/S1748013219301483
Cannabix Technologies and Omega Laboratories Inc. Provide Positive Developments on Marijuana Breathalyzer Testing • BLO • Jul 11, 2024 8:21 AM
ECGI Holdings Enhances Board with Artificial Intelligence (AI) Expert Ahead of Allon Apparel Launch • ECGI • Jul 10, 2024 8:30 AM
Avant Technologies to Meet Unmet Needs in AI Industry While Addressing Sustainability Concerns • AVAI • Jul 10, 2024 8:00 AM
Panther Minerals Inc. Launches Investor Connect AI Chatbot for Enhanced Investor Engagement and Lead Generation • PURR • Jul 9, 2024 9:00 AM
Glidelogic Corp. Becomes TikTok Shop Partner, Opening a New Chapter in E-commerce Services • GDLG • Jul 5, 2024 7:09 AM
Freedom Holdings Corporate Update; Announces Management Has Signed Letter of Intent • FHLD • Jul 3, 2024 9:00 AM