Innovation Pharmaceuticals Inc (IPIX)

[farrell90]

Brilacidin is not polymer based even though Wikipedia says it is. Its structure is based on a defensin called Magainin, a short chain peptide defensin.discovered in the 80s by Dr Zassloff.

Dr DeGrado and Polymedix developed Brilacidin by chemically strengthening Magainin's chemical core with compounds called Arylamides which allowed improved durability as well as improved pharmacokinetics. Dr DeGrado and Polymedics further optimized its function using a super computer to guide small chemical changes in its structure to enhance its antibiotic abilities.

A diagram of Manginin and Brilacidin was part of this weeks AVS presentation.page 3.

https://static1.squarespace.com/static/5715352e20c647639137f992/t/60f98b02dee5a72cfce0c44e/1626966816579/GMU+ASV+2021+Brilacidin+talk+fv+7.21.21.pdf

Actually Polymedix had success in developing a defensin mimetic polymer which they named Polycide. Polycide showed some ability as an antibiotic coating which could be used on a variety of products including surgical sutures. As far as I can tell IPIX still has the rights to Polycide.

https://www.globenewswire.com/news-release/2012/09/05/488925/16232/en/Data-Showing-Effectiveness-of-PolyCide-Antimicrobial-in-Surgical-Suture-Coatings-Published-in-American-Chemical-Society-Journal-Langmuir.html

Good luck, Farrell