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COVID-19
Literatura global sobre doença de coronavírus
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Cannabidiol Inhibits SARS-CoV-2 Replication and Promotes the Host Innate Immune Response
Este artigo é um Preprint



Cannabidiol Inhibits SARS-CoV-2 Replication and Promotes the Host Innate Immune Response
Dongbo Yang; Long Chi Nguyen; Vlad Nicolaescu; Thomas Best; Shaonong Chen; J. Brent Friesen; Nir Drayman; Adil Mohamed; Christopher Dann; Diane Silva; Haley Gula; Krysten A. Jones; J. Michael Millis; Bryan C. Dickinson; Savas Tay; Scott A. Oakes; Guido F. Pauli; David O. Meltzer; Glenn Randall; Marsha Rich Rosner.
Preprint | bioRxiv | ID: ppbiorxiv-432967
ABSTRACT
The rapid spread of COVID-19 underscores the need for new treatments. Here we report that cannabidiol (CBD), a compound produced by the cannabis plant, inhibits SARS-CoV-2 infection. CBD and its metabolite, 7-OH-CBD, but not congeneric cannabinoids, potently block SARS-CoV-2 replication in lung epithelial cells. CBD acts after cellular infection, inhibiting viral gene expression and reversing many effects of SARS-CoV-2 on host gene transcription. CBD induces interferon expression and up-regulates its antiviral signaling pathway. A cohort of human patients previously taking CBD had significantly lower SARS-CoV-2 infection incidence of up to an order of magnitude relative to matched pairs or the general population. This study highlights CBD, and its active metabolite, 7-OH-CBD, as potential preventative agents and therapeutic treatments for SARS-CoV-2 at early stages of infection.