Precision BioSciences Inc (DTIL)

[jondoeuk]

Others, such as ALLO are also working on so-called stealth cells. They plan to lower the levels of both MHC Class I and II. If NK cells reject the (CAR-T) cells, they can add an HLA-E transgene or scFv, which should stop it.

Also, this was in-licensed. The ADR recognises 4-1BB on the patient's activated T and NK cells, and mediates their elimination, effectively protecting the CAR-T cells from rejection https://www.nature.com/articles/s41587-020-0601-5