Wednesday, June 30, 2021 2:37:06 PM
I also don't know what they mean by "baseline". Is that the score on starting day?
For the raw numbers in the shown tables, note the difference between baseline and Day 56 for LL arm vs placebo in the Severe case:
LL Placebo
joint pain 2 -> 0. 3 -> 1
tightness. 6 -> 0. 3 -> 2
Numbness. 5 -> 1. 1 -> 1
Weakness 5 -> 1. 4 -> 2
Sl. disturb. 10 -> 2. 8 -> 4
Headache. 5 -> 1. 4 -> 3
Short breath. 5 -> 0. 3->2
Nausea. 1 -> 0. 2 -> 0
Granted the entire evaluation of these things looks very subjective (patients scoring themselves?) etc., still for the above symptoms (other than nausea), in the severe case, the raw numbers show there is a MASSIVE improvement in the LL arm compared to placebo. How (looking at the full tables) are you concluding the raw numbers are not impressive?
Possibly by doing biomarker analysis, Dr. Recknor will deduce more detail behind the chemical activity of Leronlimab that caused these dramatic changes in the severe case for these symptoms.
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