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Monday, June 28, 2021 11:51:37 AM
Baseline (I am guessing) is the initial scoreline for patients at the time of entry
Day 56 is the evaluation at Day 56. Or it is based on an average of the daily scores till day 56. In the latter case, the scores of a patient may be averaged over the 56 days and if it (for instance) averages to 2.6, the patient would be considered severe; whereas if was 2.42, it would be rounded below and the patient would be regarded as moderate.
Each patient is evaluated (don't know how) for whether their condition is severe, ..., none. And accordingly there is a score assigned: severe = 3...
The entries in the main columns are the number of patients who are evaluated as having this level.
Take the table for Tightness in Chest.
There were 6 patients in the LL arm who had severe tightness in chest at the baseline and by Day 56, there were 0 LL patients with severe tightness. Whereas in the placebo arm, 3 at baseline and 2 at Day 56.
Likewise for the other 3 rows.
The 5th row (which shows 16 for Day 56 and 35 for Baseline) is the Total Sum of the Scores for the patients at Day 56 and Baseline.
So for Day 56, the Total Score is 0 x 3 + 4 x 2 + 8 x 1 + 16 x 0 = 16 (since 0 patients had score 3, 4 had score 2, etc.) Similarly for LL baseline, total score is 6 x 3 + 5 x 2 + 7 x 1 + 10 x 0 = 35.
The net change in score between baseline and Day 56 is 16 - 35 = -19 for the LL arm and 19 - 26 = -7 for the Placebo arm.
The % improvement between placebo and LL is (19 - 7)/7 x 100 ~ 171 %.
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