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Nasal Vaccines for COVID-19

Safety is another consideration. The majority of mucosal vaccines licensed in the U.S. are delivered via the oral route. Perhaps because of closer proximity to the brain, vaccine regulators appear to have shied away from the intranasal route. For example, Berna Biotech’s inactivated intranasal influenza vaccine was discontinued in Switzerland after it was found to be associated with increased risk of Bell’s Palsy.

Still, because oral vaccination tends to produce an antibody response that is not so strong in the respiratory tract, Russell contends that intranasal immunization “makes the most sense” for a respiratory pathogen like SARS-CoV-2.

“If similar resources can be made available for the accelerated development of intranasal vaccines, as have been deployed for the existing vaccines, my guess is that we might see some of them becoming available within about a year,” he said.

Why would they mention Berna Biotech in this Article??

https://www.nanovaccine.iastate.edu/researchers/richard-kennedy-phd/nasal-vaccines-for-covid-19/


Intranasal vaccines aim to stop COVID-19 where it starts
cen.acs.org › pharmaceuticals › vaccines
Jun 06, 2021 · An intranasal flu vaccine made by Berna Biotech and approved in Switzerland in 1997 was linked to rare cases of Bell’s palsy—a usually temporary facial paralysis—after it was commercialized.

https://cen.acs.org/pharmaceuticals/vaccines/Intranasal-nose-vaccines-stop-COVID/99/i21