Tuesday, January 23, 2007 9:08:47 PM
Too, frog, I think CNVs are overrated. The company has been doing very well with SNPs in their Ancestry and forensic work.
According to you, they couldn't be!
The reality is they are not doing very well at all, are they? If SNP's were what they were supposed to be, then all of those other traits that were pumped in the beginning would now be detectable.
Hair color, nose shape, brow ridge, physique, etc., all should be nailed down by now. Not to mention a better resolution on ancestry than just the four skin color groups.
The most likely reason that these features have escaped detection for so long is the probability that the genetic variants responsible are somewhere in that 90% of variances that is invisible to SNP detection.
To go even further it is the most likely reason for the failures of any of the classifiers to achieve completion.
regards,
frog
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