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Wednesday, 06/09/2021 2:22:00 PM

Wednesday, June 09, 2021 2:22:00 PM

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Do investors in PALI still have any hope for NSI-189 in Alzheimer’s Disease which is shown to be safe and induces anatomically proven neurogenesis in human hippocampus?

The drug failed in phase 2 for Major Depression several years ago. Perhaps dementia treatment is where the drug belongs.

Being shown to be safe, is there any chance of a “Right to Try” of NSI-189 for patients who are experiencing a cognitive decline and have no real treatments other than the BIIB drug ,recently approved, which has shown a minimal clinical benefit in the phase 3 trials? The BIIB drug showed a 6% rate of worrisome brain inflammation. NSI-189 is already shown to be safe and did help patients clinically in cognitive tests, but did not help with their depression.

NSI-189 was developed when our company was called NeuralStem I think.

Thanks.

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