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Tuesday, June 08, 2021 11:06:45 AM
You know better than anyone that the road to therapeutic Nirvana is paved with land mines...The role of Beta amyloid in the pathogeneses of Alzheimer's Dementia has never been elucidated, and remains one of the great mysteries of clinical medicine..
There exists oblique evidence that suggest that dementia is not created by focal disruption...Multiple Sclerosis is an auto immune disease that results in focal areas of neural loss both above and below the Foramen Magnum...Although MS patients can develop cognitive issues in most cases this is not the impressive aspect of the condition like dementia is in AZ..
If Beta A was the prime cause it would have to function by creating focal disruptions (like MS does)..Most AZ cases begin with personality changes..
Interestingly...Jealousy is a frequent prodrome..
Finally AZ is a disease of aging...And those of you are are veterans of the Vascepa wars know and understand the ravages of aging are principally the effects of inflammation. I would bet AZ is no exception to the rule...Why should it be...
In would like to see a a race between Vascepa and the BIIB drug and would bet heavy money on Vascepa...
Hope all is well
":>)JL
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