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Re: olden_grumpini post# 361571

Friday, 06/04/2021 4:54:23 PM

Friday, June 04, 2021 4:54:23 PM

Post# of 403328
Could you please provide the quote that Remdesivir was 99% on a stand alone basis?

Here's what I read: "In contrast, combination of brilacidin with remdesivir at 10 and 2.5 µM concentrations, respectively, reduced the viral infectious titer by >99%, thus providing a highly effective inhibition profile (Figure 5B) and achieving greater inhibition than with either compound alone. This synergistic inhibition continued to remain higher than 99% when the concentrations of both compounds were equal (2.5 µM each)".

The combination was 99%. In fact, when Remdesivir was reduced by 75%, he reduction remained at 99%.

I could have missed the Remdesivir alone, so please p;rovide.

Thanks, Paul
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