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Targeting HER-2/neu with Antirat Neu Virosomes for Cancer Therapy
cancerres.aacrjournals.org › content › canres
use of doxorubicin (Doxo) as a cytotoxic drug. We have used virosomes (Vir; reconstituted fusion-active viral envelopes) as a new drug delivery system and have shown that Vir are capable of binding and penetrating into tumor cells, delivering cytotoxic drugs. We have additionally demon-strated that conjugating Fab fragments of an antirat Neu ...

[CANCER RESEARCH 62, 437–444, January 15, 2002]
Targeting HER-2/neu with Antirat Neu Virosomes for Cancer Therapy1
Ernst Waelti,2 Nina Wegmann,2 Ruth Schwaninger, Antionette Wetterwald, Carsten Wingenfeld,
Barbara Rothen-Rutishauser, and Claude D. Gimmi3
Department of Clinical Research [W. N., S. R., W. A., W. C., C. D. G.], Institute of Pathology [W. E.], and Institute of Anatomy [R-R. B.], University of Bern, 3010 Bern,
https://cancerres.aacrjournals.org/content/canres/62/2/437.full.pdf

Nanotechnology Based Virosomal Drug Delivery Systems
www.ommegaonline.org › article-details
Dec 15, 2014 · Fab'-Doxo- virosomes combined the anti-proliferate properties of the monoclonal antibody and the cytotoxic effect of doxorubicin in vivo. Fab'-Doxo-virosomes significantly inhibited tumour formation at a tumour load of metastasis spread, indicating that this can also be considered to be a promising new selective drug delivery system for the treatment of tumours expressing a specific tumour antigen.

Author: Basavaraj K. Nanjwade, Nagi F. Idris, Ramchandra N. Chilkawar, Teerapol Srichana, Azam Sharif Md. Sh...
Cited by: 1