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Major step forwards for vaccine against cervical cancer

Dutch researcher Laura Bungener has developed a vaccine against cervical cancer. Vaccinated laboratory animals no longer developed the disease and animals which had already developed a tumour, could be treated with the vaccine.

Human papillomavirus (HPV) is the virus responsible for cervical cancer.

Bungener also investigated the mechanism underlying the vaccinations by using model proteins in 'recombinant Semliki Forest virus' and in the virosomes.

The doctoral thesis was defended on 6 December 2004, supervisor Prof. J.C. Wilschut

https://www.eurekalert.org/pub_releases/2004-12/nofs-msf121604.php

The research was funded by the Netherlands Organisation for Scientific Research.

https://en.wikipedia.org/wiki/Dutch_Research_Council

NWO directs its approximate budget of 1 billion euros towards Dutch universities and institutes, often on a project basis. Also, NWO has its own research institutes and facilitates international cooperation

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Thus, virosomes represent an excellent
vaccine delivery system for induction of cellular immunity against encapsulated HPV16 E7 and are a promising immunotherapeutic vaccine for treatment of (presursor lesions
of) cervical cancer.
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Chapter 6

nucleocapsid, and subsequent reconstitution of the viral phospholipids and glycoproteins into vesicles [Almeida 1975, Stegmann 1987, Bron 1993].

Preparation and characterization of E7 virosomes
Virosomes were prepared from H3N2 subtype influenza virus (A/Panama/2007/99, a gift from Solvay Pharmaceuticals, Weesp, The Netherlands) as previously described [Stegmann 1987, Bron 1993, Bungener 2002]

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