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Re: bow-tie post# 25079

Sunday, 05/23/2021 11:08:03 AM

Sunday, May 23, 2021 11:08:03 AM

Post# of 27659
MHC class I and MHC class II reside on antigen-presenting cell (APCs) surface. MHC-I presentation pathway simulated the CD8+ cytotoxic T lymphocytes (CTLs) and MHC-II antigen leading to activated CD4+ helper T cells pathway. APCs uptake antigens and transport them into draining lymph nodes, crucial for induction of a long-lived memory and robust IgG response [44,49,50].

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8049750/figure/f0020/?report=objectonly

44. Bungener L., Huckriede A., de Mare A., de Vries-Idema J., Wilschut J., Daemen T. Virosome-mediated delivery of protein antigens in vivo: efficient induction of class I MHC-restricted cytotoxic T lymphocyte activity. Vaccine. 2005;23(10):1232–1241. [PubMed] [Google Scholar]

49. Stegmann T., Kamphuis T., Meijerhof T., Goud E., de Haan A., Wilschut J. Lipopeptide-adjuvanted respiratory syncytial virus virosomes: a safe and immunogenic non-replicating vaccine formulation. Vaccine. 2010;28(34):5543–5550. [PubMed] [Google Scholar]

50. Kammer A.R., Amacker M., Rasi S., Westerfeld N., Gremion C., Neuhaus D., Zurbriggen R. A new and versatile virosomal antigen delivery system to induce cellular and humoral immune responses. Vaccine. 2007;25(41):7065–7074. [PubMed] [Google Scholar]

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