This is a quote from (probably) the most knowledgeable person in the world on CNS drug development:
P value is near irrelevant with this tiny sample size. I’ve seen ‘statistically significant’ changes in pilot studies vaporize many times when larger studies were carried out. And for them to issue a press release comparing their 14 patients at 25 days with Biogen’s 1638 patients at 18 months is the most inappropriate comparison I have ever seen in 26 years of doing this. That press release will be Exhibit #1 if they ever are targeted by a shareholder suit.
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