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Tuesday, May 11, 2021 10:08:57 AM
The trial also had less efficacy with patients 85 years old and older. This also makes sense. A person needs a good immune system to reach the age of 85. 85+yo don't experience the cytokine storm much and have done far better than younger age groups.
Lenz's whole study has 54% efficacy but further analysis brings some eyepopping results. Patients who are treated when they have been hospitalized for 2 days or less have 88% efficacy. When patients 85+ and patients in the advanced stage of severe aren't included, efficacy on preventing mechanical ventilation goes up to 296%. The mortality benefit in this same group is 217%.
Naysayers might argue that I am datamining or cherry picking but I disagree. It could have been predicted that the 85+ and advanced stage severe patients wouldn't have efficacy. I think the FDA will give an EUA and give guidance that patients should be administered lenzilumab immediately after being hospitalized. Unfortunately, the 85+ age group might have to be excluded or it could possibly be left up to the physician.
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