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Re: misiu143 post# 164655

Tuesday, 05/11/2021 1:31:39 AM

Tuesday, May 11, 2021 1:31:39 AM

Post# of 233221

And according to dr Patterson only about 20-25% patients with covid showing higher GM-CSF.


And the patients who have elevated GM-CSF are the exact patients who go on to be severe and die. Patients who don't have elevated GM-CSF will recover on their own.

Obviously, lenzilumab being an GM-CSF inhibitor puts it in a nice position to be a game changing Covid treatment. But any treatment could use GM-CSF detection in their trial. For instance, leronlimab could redo their mild-to-moderate trial while only giving it those with elevated GM-CSF. Their efficacy would be much better. Maybe they could even show a mortality benefit by targeting the patients who are the ones at risk of becoming severe and dying.

https://www.bbc.com/news/health-56352128
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