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Monday, May 10, 2021 5:52:49 PM
There are other indications that may involve VIP as an active drug product including acute and chronic inflammatory and autoimmune diseases, such as septic shock, rheumatoid arthritis, multiple sclerosis, Crohn’s disease or autoimmune diabetes. VIP can actually be used in these
conditions to inhibit the autoimmune response.
In cancer, VPAC1 receptors may be molecular targets for diagnosis, prevention and treatment of breast cancer, as well as lung cancer. Radio labelled VIP analogues have been developed for imaging of lung and breast cancer.
Synthetic VIP receptor antagonists inhibited the proliferation and potentiated the ability of chemotherapeutic agents to cause apoptosis of lung and breast cancer cells. VIP-chemotherapeutic conjugates have been synthesized which bind to VPAC1 receptors and are internalized, resulting in the killing of lung and breast cancer cells.
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