Humanigen Inc (HGENQ)

[DonDonDonDon]

SWOV also relatively improved by 92% in subjects who received
both corticosteroids and remdesivir (1.92; 1.20-3.07, nominal p=0.0067); by 2.96-fold in
subjects with CRP<150 mg/L and age <85 years (2.96; 1.63–5.37, nominal p=0.0003);
and by 88% in subjects hospitalized ≤2 days prior to randomization (1.88; 1.13-3.12,
nominal p=0.015). Survival was improved by 2.17-fold in subjects with CRP<150 mg/L
and age <85 years (2.17; 1.04-4.54, nominal p=0.040)

The above findings are consistent with what was already believed.

People over 85 years old only make it to that age if they have a good immune system. They don't experience the cytokine storm as much and have a lower mortality rate than 70-80 year olds. So having less efficacy with them is natural since lenzilumab works by preventing the cytokine storm.

Patients in a more advanced stage of Covid also had lower efficacy. This also makes sense. The cytokine storm has already done damage. It makes sense to use lenzilumab when the cytokine storm is just starting. Since every patient goes through the beginning stage of severe, not treating advanced severe patients wouldn't really reduce lenz's potential market. Patients should receive lenz as soon as they are hospitalized for the greatest efficacy.

2.96 fold efficacy. I like the sound of that.