Cytodyn Inc (CYDY)

[Learning53]

A Bibliography (revised May 7, 2021)

Important Links RE: Cytodyn/Leronlimab
(not including “Official” CytoDyn Inc. items)
Compiled mostly after 1-1-2021



Leronlimab Indications
(just a few of many see - https://investorshub.advfn.com/boards/read_msg.aspx?message_id=163139339)


Breast Cancer

Leronlimab blocks breast cancer cellular metastasis and enhances cell death induced by DNA damaging Chemotherapy
2021 Jan 23
https://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-021-01391-1

Metastatic Triple Negative Breast Cancer (mTNBC) Market 2030: Epidemiology Analysis, Key Companies, Emerging Drugs and Competitive Analysis by DelveInsight
2021 Apr 28
https://reportedtimes.com/metastatic-triple-negative-breast-cancer-mtnbc-market-2030-epidemiology-analysis-key-companies-emerging-drugs-and-competitive-analysis-by-delveinsight/

Role of Leronlimab in Triple Negative Breast Cancer by Scot Kelly ME – Chief Medical Officer and CEO of Cytodyn
April 2021
https://d1io3yog0oux5.cloudfront.net/cytodyn/files/video/TNBC.mp4?fbclid=IwAR3t6b4fUJm4epDaaK0cXIpgRCEHzk32Lv2IpEsHoLwDSJ2wCvr0qX6q_Ds



HIV

Anti-HIV-1 activity of weekly or biweekly treatment with…PRO 140…
2010 May 15
https://pubmed.ncbi.nlm.nih.gov/20377413/


CytoDyn HIV Indication Update:Leronlimab HIV Extension Arm Nearing 7 Years with Continued Excellent Safety Results
2021 May 03
https://finance.yahoo.com/news/cytodyn-hiv-indication-leronlimab-hiv-130000387.html



Long Haulers

Covid-19 Long Hauler Hopes to Benefit From Loal FDA Trial Therapy (Story of Eli Musser)
2021 Feb 17
https://www.nbcmiami.com/news/local/covid-19-long-hauler-hopes-to-benefit-from-local-trial/2385419/


Covid-19 damages brain without infecting it, study suggests
2021 Apr 19
https://www.cidrap.umn.edu/news-perspective/2021/04/covid-19-damages-brain-without-infecting-it-study-suggests



Covid-19 alters human genes, explaining mystery behind coronavirus “Long Haulers”
2021 Apr 28
https://www.studyfinds.org/covid-alters-genes-long-haulers/


COVID “long haulers” with Drs. Paterson and Yo + Jenny Hobbs with Dr. Bream
2021 Apr 11
https://www.facebook.com/events/141961851200739/



Glioblastoma

An Update on Glioblastoma Biology, Genetics, and Current Therapies: Novel Inhibitors of the G Protein-Coupled Receptor CCR5
2021 Apr 4
https://res.mdpi.com/d_attachment/ijms/ijms-22-04464/article_deploy/ijms-22-04464.pdf


Covid-19

The bulk of this bibliography is re: Leronlimab (aka Vyrologix, aka Pro 140) and its ability to safely treat patients in various stages of Covid-19



Leronlimab Drug Physical Factors and Mechanism(s) of Action (MOA)

Absorption

Antibody Drug Absorption… from Journal of Clinical Pharmacology
2013
https://accp1.onlinelibrary.wiley.com/doi/pdf/10.1002/jcph.4

Mechanism(s) of Action (MOA)

Pharmacokinetic of Monoclonal Antibodies
2017 Jul 29
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613179/

Disruption of the CCL5/RANTES-CCR5 Pathway Restores Immune Homeostasis and Reduces Plasma Viral Load in Critical COVID-19 Bruce Patterson, et al
2020 May 5
https://www.medrxiv.org/content/10.1101/2020.05.02.20084673v1

METHODS FOR TREATING OR PREVENTING CANCERS INVOLVING THE ADMINISTRATION OF ANTI-CCR5 RECEPTOR AGENTS
2020 Jul 30
https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2021026028&tab=PCTDESCRIPTION


CCR5 INHIBITION IN CRITICAL Covid-19 patients decreases inflammatory cytokines, increases CD8
T-cell, and decreases SARS-CoV2 RNA in plasma by day 14 Bruce Patterson, et al.
2021 Feb 01
https://www.ijidonline.com/article/S1201-9712(20)32305-5/fulltext


Novel CCR5 Antagonist for the Treatment of Mild-Moderate COVID-19 Infection after Lung Transplant involves leronlimab
2021 Apr
https://www.researchgate.net/publication/350224402_Novel_CCR5_Antagonist_for_the_Treatment_of_Mild-Moderate_COVID-19_Infection_after_Lung_Transplant



Leronlimab/aka Vyrologix/ aka Pro 140 TRIAL/Study results and comments

CD 12

A New Look At Cytodyn’sSever-To-Critical Covid-19 Trial from Seeking Alpha
2021 Mar 17
https://seekingalpha.com/article/4414628-new-look-cytodyn-stock-severe-to-critical-covid-19-trial

Cytodyn’s Smoking Gun for an Immediate EUA from insider Financial
2021 Mar 23
https://insiderfinancial.com/cytodyns-smoking-gun-for-an-immediate-eua/181182/

6 Endpoints Met After Full Data Release So Shorts Double Down On Trial Failure
2021 Mar 14
https://insiderfinancial.com/cytodyn-saves-lives-reduces-covid-19-hospital-duration/181154/


CytoDyn (OTCQB: CYDY) Stuns FDA with 400% Improvement in 14 Day Mortality – Emerging Growth
2021 Mar 30
https://emerginggrowth.com/cytodyn-otcqb-cydy-stuns-fda-with-400-improvement-in-14-day-mortality/


CD 16 and 17


CytoDyn and AEIH to begin trials of leronlimab in Critical and Severe Covid-19
2021 May 06
https://www.clinicaltrialsarena.com/news/cytodyn-aeih-trials-leronlimab/








Anecdotal Results and Information

Clinical Characteristics and Outcomes of Coronavirus Disease 2019 Patients Who Received Compassionate – Use Leronlimab Bryand Yang et al From Clinical Infectious Diseases
2020 Oct 20
https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciaa1583/5932277?login=true

Disruption of CCR5 signaling to treat Covid-19 associated cytokine storm: Case series of four critically ill patients treated with lerolimab From Journal of Translational Autoimmunity Vol 4, 2021, 100083 Nicholas Agresti, et al
2021
https://www.sciencedirect.com/science/article/pii/S2589909021000034

Case Study of a Critically Ill Person With Covid-19 on ECMO successfully treated with leronlimab
2021 Mar 23
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7985604/

Ex-President Erap being treated with Leronlimab
2021 Apr 19
https://mb.com.ph/2021/04/19/ex-pres-erap-being-treated-with-leronlimab/


Experimental COVID treatment may have saved ND woman's life; doctor says more study needed
2021 May 01
https://www.thedickinsonpress.com/newsmd/coronavirus/7008927-Experimental-COVID-treatment-may-have-saved-ND-womans-life-doctor-says-more-study-needed


Leronlim Being Used To Fight Covid-19
2021 Apr 29
https://www.youtube.com/watch?v=p4xkkz9-rxY


Coronavirus patients taken off ventilators after getting experimental HIV drug (included because it’s one of the earliest mentions of leronlimab back when little was known about the virus and death was widespread)
2020 Mar 28
https://nypost.com/2020/03/28/coronavirus-patients-taken-off-ventilators-after-getting-experimental-hiv-drug/





Cytodyn Strategy

Cytodyn’s pivot strategy favors Philippine EUA and Long Haulers
2021 Apr 25
https://insiderfinancial.com/cytodyns-pivot-in-strategy-favors-philippine-eua-and-long-haulers/181303/



News Reports

Philippines

Maker discovers overpriced Remdesivir in some PH hospitals (1:04 news report) video
2021 Apr 22
https://www.youtube.com/watch?v=N9h8wFNRdSs

Leronlimab Being Used to Fight Covid-19 (In Philippines including saving ex-President Estrada
(Philippine newscaster interviewing Dr Nicolas talking about how leronlimab saved the Ex-President’s life)
2021 April 29
https://www.youtube.com/watch?v=p4xkkz9-rxY

No compassion in compassionate use by Cito Beltran (Not a news report but a commentary)
2021 Apr 12
https://www.philstar.com/opinion/2021/04/12/2090545/no-compassion-compassionate-use



VACCINE COMMENTS/INFORMATION:


Bombshell: Moderna Chief Medical Officer Admits MRNA Alters DNA (also mention of Fauci in it)
2021 Mar 12
https://sonsoflibertymedia.com/bombshell-moderna-chief-medical-officer-admits-mrna-alters-dna/

Covid-19: mRNA vaccines reduce symptom-free cases by 80% (people with two doses less likely to be asymptomatic and spread the virus)
2021 Mar 16
https://www.medicalnewstoday.com/articles/covid-19-mrna-vaccines-reduce-symptom-free-cases-by-80

246 Fully vaccinated Michigan residents test positive for Covid and three die
2021 Apr 6
https://news.yahoo.com/246-fully-vaccinated-michigan-residents-165337809.html


Reaching “Herd Immunity” Is Unlikely in the U.S., Experts Now Believe
2021 May 03
https://www.nytimes.com/2021/05/03/health/covid-herd-immunity-vaccine.html


“Dr. Rajendra Kapila, infectious disease expert with Rutgers University was…”
2021 May 03
https://twitter.com/in_environ/status/1389322921152335875?s=20
(also cross-posted in variants)


“ANTI-VAXXER” INFO AND COMMENTS”
(????? OPEN TO DEBATE ?????)

18 Reasons I Won’t Be Getting a Covid Vaccine by Christian Elliot
2021 Apr 5
https://www.deconstructingconventional.com/post/18-reason-i-won-t-be-getting-a-covid-vaccine


Prion disease risk and other adverse effects from vaccination with RNA based SARS-CoV-2 vaccines
2021 Jan 18
https://scivisionpub.com/pdfs/covid19-rna-based-vaccines-and-the-risk-of-prion-disease-1503.pdf


Mass Vaccination in a Pandemic – Benefits versus Risks: Interview with Geert Vanden Bossche
2021 Mar 6
https://www.youtube.com/watch?v=ZJZxiNxYLpc&t=2128s




Anthony Fauci
(Dr. Fauci is included since he is pivotal in Covid-19 Drug and Treatment decisions. IMO)

Where did Covid-19 originate and Gain-of-Function and Fauci
2020 Jun 4
https://www.ellsworthamerican.com/opinions/letters-to-the-editor/dr-fauci-the-untold-story/

An Open Letter to Dr. Anthony Fauci (HIV re Fauci’s mismanagement of the program and needless deaths
2004 Dec 7
https://www.villagevoice.com/2020/05/28/an-open-letter-to-dr-anthony-fauci/


Biological Security: The Risk Of Dual-Use Research Hearing before the Committee on Homeland Security and Governmental Affairs US Senate
2012 Apr 26
https://www.govinfo.gov/content/pkg/CHRG-112shrg75273/html/CHRG-112shrg75273.htm




Analysis and Critique – Vaccines and Treatments – Safety and Efficacy


Dr. Bream and Dr. Been (Dr. Mobeen Syed) Present and discuss the current vaccines, treatments, supportive (or not) research, results, applicability, comments.
2021 Apr 27
https://www.facebook.com/breammedical/videos/?ref=page_internal



Corona Virus Mutations and Variants


Corona-19 variants: Five things to know about how coronavirus is evolving
2021 Mar 29
https://horizon-magazine.eu/article/covid-19-variants-five-things-know-about-how-coronavirus-evolving.html


Corona Virus Mutations and Variants – What does it mean?
2021 Apr 01
https://srhd.org/news/2021/coronavirus-mutations-and-variants-what-does-it-mean


GOING VIRAL ‘World’s most mutated’ Covid Strain with 34 mutations is found as fears grow super-variant may prolong pandemic
2021 Apr 21
https://www.thesun.co.uk/news/14667687/scientists-world-most-mutated-covid-strain/


Triple-mutant ‘Bengal strain’ a new worry in second wave
2021 Apr 22
https://timesofindia.indiatimes.com/city/kolkata/triple-mutant-bengal-strain-a-new-worry-in-second-wave/articleshow/82188085.cms


Israel COVID-19 study finds South Africa variant able to ‘break through’ Pfizer vaccine
2021 Apr 11
https://www.foxnews.com/health/israel-covid-19-study-south-africa-variant-pfizer-vaccine


“Dr. Rajendra Kapila, infectious disease expert with Rutgers University was…”
2021 May 03
https://twitter.com/in_environ/status/1389322921152335875?s=20


South India’s N440K Covid Variant 15 times more lethal
2021 May 04
https://www.businesstoday.in/latest/trends/south-india-n440k-covid-variant-15-times-more-lethal/story/438271.html






Big Pharma and Resistance

Big Pharma

Big Pharma blocking Leronlimab’s use…
2021 Apr 22
https://opinyon.net/national/big-pharmas-blocking-leronlimab-s-use-against-covid-19

Better Than Vaccines (looks like the writer was from the Philippines as was his point of view)
2021 Apr 25
https://opinyon.net/national/better-than-vaccines



Shorts and Stock Market Manipulation

Stat and the Short Mafia including Adam Feuerstein
2021 Feb 1
https://insiderfinancial.com/reddit-rebellion-targeting-the-short-mafia-next/180939/


6 Endpoints Met After Full Data Release So Shorts Double Down On Trial Failure
2021 Mar 14
https://insiderfinancial.com/cytodyn-saves-lives-reduces-covid-19-hospital-duration/181154/


Misleading Headline on CydoDyn (CYDY) Triggers Algo Selling (this is re: the short attack of 6/30/2020
Also in the article CytoDyn is misspelled as CydoDyn)
2020 Jul 01
https://emerginggrowth.com/misleading-headline-on-cydodyn-cydy-triggers-algo-selling/


Stock short attack analysis (From the Wizard of Vegas ? but does treat the short attack on Cytodyn that occurred June 30, 2020)
2020 Aug 16
https://wizardofvegas.com/forum/off-topic/off-topic/35005-stock-short-attack-analysis/


Fairly comprehensive post from InvestorsHub CYDY discussion board this includes many useful links
2021 Feb 02
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=161409865



Leronlimab Compendium

From Reddit a series of Articles, videos, posts
from April 24th to April 30
https://www.reddit.com/r/CYDY/comments/n0gv2g/why_cydy_stock_always_red_here_is_the_answer/


CytoDyn – Vyrologix (leronlimab; Pro-140) This is a short history of leronlimab’s “journey” in response to Covid-19. It’s considered a Covid-19 Front Runner
2020 May 18
https://www.genengnews.com/covid-19-candidates/cytodyn/


Friends of Leronlimab – A New Therapeutic Drug for Covic #Leronlimab
This is a collection which covers a number of topics.
2021 Apr (This is unclear but a fair estimate)
https://www.getleronlimab.com/



OTHER ASSORTED “STUFF”:

Drugs/Treatments approval in question or rescinded

FDA Busts Merck’s Keytruda in Triple-negaitve breast cancer with a CRL – not unexpectied given its disastrous adcomm (FDA shows Keytruda the door)
2021 Mar 29
https://endpts.com/fda-busts-mercks-keytruda-in-triple-negative-breast-cancer-with-a-crl-not-unexpected-given-its-disastrous-adcomm/

FDA’s Approval of Covid-19 Treatment Should Be Promptly Revisited in Consultation With Outside Experts (This is about Remdesivir and its questionable approval)
2021 Apr 21
https://www.citizen.org/news/fdas-approval-of-covid-19-treatment-should-be-promptly-revisited-in-consultation-with-outside-experts/

Coronavirus (COVID-19) Update: FDA Revokes Emergency Use Authorization for Monoclonal Antibody Bamlanivimab
2021 Apr 16
https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-revokes-emergency-use-authorization-monoclonal-antibody-bamlanivimab?utm_medium=email&utm_source=govdelivery


COVID-19 STATISTICS RE: AGE/HOSPITALIZATION/DEATH

Risk for COVID=19 Infection, Hospitalization, and Death By Age Group from CDC Chart
2021 Feb 18
https://www.cdc.gov/coronavirus/2019-ncov/covid-data/investigations-discovery/hospitalization-death-by-age.html


TESTIMONY ON “LACK OF TREATMENTS” AND INFORMATION FOR PATIENTS W/ COVID

Peter McCullough, MD testifies to Texas Senate HHS Committee – need for treatments and information
2021 Mar 11
https://www.youtube.com/watch?v=QAHi3lX3oGM

BOOKLET – a Guide to Home-Based Covid Treatment
https://aapsonline.org/CovidPatientTreatmentGuide.pdf



MESSAGES RE: WE NEED LERONLIMAB NOW – AS A TREATMENT!

Letter from Dr. Bream To Dr. Woodcock to save life plus more from Reddit
2021 March end approx.
https://www.reddit.com/r/CYDY/comments/m0ko1m/letter_from_dr_bream_to_dr_woodcock_to_save_life/


Leronlimab : The Little Drug That Could 3:06 plea to end politics and approve leronlimab Dr. Bream
2021 April 30
https://www.youtube.com/watch?v=fHbF6nWzbe8



Miracle Molecule Leronlimab – LTRS FROM COVID-19 DR’S TO DR. JANET WOODCOCK SUPPORTING LERONLIMAB EUA (The letters and more)
2021 April
https://miraclemolecule.online/




CONCERNS ABOUT FDA IMPARTIALITY AND BP’S UNDUE INFLUENCE OVER ITS DECISIONS

New Harvard study reveals Institutional Corruption of Pharmaceuticals and how FDA cannot be trusted with public safety
2021 Mar 8 (not positive about this)
https://www.seattleorganicrestaurants.com/vegan-whole-food/institutional-corruption-of-pharmaceuticals-how-FDA-cannot-be-trusted-with-public-safety.php


Hidden Conflicts? Pharma payment to FDA advisers after drug approvals spark ethical concerns by Charles Piller, Jia You
2018 Jul 5
https://www.sciencemag.org/news/2018/07/hidden-conflicts-pharma-payments-fda-advisers-after-
drug-approvals-spark-ethical


An FDA official who led the approval of OxyContin got a $400,000 gig at Purdue Pharma a year later, a new book reveals
2021 May 2
https://www.businessinsider.com/fda-chief-approved-oxycontin-six-figure-gig-at-purdue-pharma-2021-5



Appendix A, Table 2. COVID-19 Treatment Guidelines Panel Financial Disclosure for Companies Related to COVID-19 Treatment or Diagnostics (List of personnel and financial disclosures)
2021 Apr 21
https://www.covid19treatmentguidelines.nih.gov/panel-financial-disclosure/


The Biopharmaceutical Industry Provides 75% Of The FDA's Drug Review Budget. Is This A Problem?
2018 Jun 28
https://www.forbes.com/sites/johnlamattina/2018/06/28/the-biopharmaceutical-industry-provides-75-of-the-fdas-drug-review-budget-is-this-a-problem/?sh=5aecba2c49ec




Estimate of Market Potential for Leronlimab (?????)


Market potential of the drug leronlimab by Cytodyn (IMO – who knows?? – We’ll see.)
2021 April 22 (approx. – not stated in article)
https://drive.google.com/file/d/1EQI547nVbzxnHc4xPnGEwbL4B0Uc8miA/view?ths=true


***



Finally, Please note that these resources do NOT include official Cytodyn Inc. news and/or press releases!

The “Official” CytoDyn Inc. news, events, and press releases are available here:
https://www.cytodyn.com/newsroom/press-releases

These will augment the preceding information and are well worth exploring for a comprehensive view.