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jondoeuk

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jondoeuk

Re: jondoeuk post# 14

Friday, 04/30/2021 9:59:09 PM

Friday, April 30, 2021 9:59:09 PM

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Adding CD8 coreceptors may enhance CD4+ T-cell responses (for MHC Class I-restricted antigens) by stabilising TCR-pMHC interactions. Also, it serves to enhance avidity from low affinity TCRs, while enhancing activation https://www.tandfonline.com/doi/full/10.4161/onci.22590

Another way would be to target MHC Class II-restricted antigens https://www.jci.org/articles/view/120391
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