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Relationship between TNF and NF-kB

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leifsmith   Thursday, 04/29/21 08:56:14 AM
Re: SeanVan post# 26
Post # of 76 
Relationship between TNF and NF-kB
Quote:
Tumor Necrosis Factor (TNF) has a crucial role in inflammation, cell proliferation and cell death. Dysregulation of TNF receptor 1 (TNFR1)-induced Nuclear Factor-kappa B (NF-kB) signaling leads to chronic inflammation and is associated with several human inflammatory pathologies. Hence, TNF neutralization suppresses inflammation and attenuates inflammatory pathology. However, despite its beneficial effects, anti-TNF therapy suffers from efficacy issues and severe immune side effects. There is thus an urging [sic] need to identify novel targets for pharmaceutical intervention in the NF-kB signaling pathway.

Found here: https://www.nature.com/articles/sdata2018289

Now read SeanVan's post again: https://investorshub.advfn.com/boards/read_msg.aspx?message_id=163483867

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