KARADAJIAN explains how important Abivertinib is!
"Understanding Abivertinib:
Some people seem to be unsure about how legit SRNE chances are of actually generating revenue. So let's take a look at the drug in the most advanced stage of it's pipeline: Abivertinib
Ok, so 1st of all, we are explaining Abivertinib as it relates to its original use target: lung cancer.
Lung cancer is the most common cancer worldwide, so drugs that can successfully treat it have a huge market.
Abivertinib isn't useful for all types of lung cancer patients, most probably for about 15-20% at most. Still, this is a big market, even before we get into covid.
Abivertinib is a 3rd generation EGFR inhibitor. Now, what does that mean?
1st, it means this is a relatively new type of drug. It's not a breakthrough in itself, but the effectiveness of Abivertinib seems to be. So, one thing we know, it's high tech, so to speak.
2nd, the advantage of it not being totally new: similar 3rd generation inhibitors have been approved by the FDA. So part of the approval process has already been overseen and these inhibitors have proved their worth.
Now, what does it actually do? Well, to explain it simply:
A certain drug is given to patients with lung cancer, that works. But after several months (up to a year), the drugs are no longer effective.
To make them effective, 2nd generation inhibitors are used (remember, Abivertinib is 3rd generation). But, these 2nd generation, have an issue: all these inhibitors (from all generations) inhibit a certain type of protein that helps the cancer spread. By inhibiting the protein, they halt the spread of the tumor. But, the 2nd generation drugs, they also inhibit the "good proteins", so the dosage has to be low. In other words, there is only so much of those 2nd generation drugs that can be given to the patient. It's a problem.
So 3rd generation inhibitors where created and received approval. What makes these special: they are able to inhibit only the "bad protein" without inhibiting "good protein". Or at least, way more effectively than 2nd generation at doing that.
Why is Abivertinib special? First of all, it's more effective. It does its job better. In trials, it is more powerful than all current 3rd generation inhibitors.
Also, it seems to use a different "approach" to inhibiting, called a different "path". So it's actually doing something that hasn't been seen before. And doing it really well, while also being less toxic.
Now, how does this relate to covid? Well, as we all know, covid attacks the lungs. And one way to treat it is using inhibitors. These are called BTK inhibitors. Which basically means, they inhibit a different type of protein that helps covid spread its attack. So to speak.
The problem has been that the current BTK inhibitors in the market, which were a big hope for treating covid, failed. They just didn't work.
And yes, you guessed it, Abivertinib IS a BTK inhibitor, which currently seems to be far and away the best option out there for treating covid. Really, it is. In trials, Abivertinib is working very, very well in a very small but significant sample.
This does/did two things. One, it opened up the option for Sorrento to offer this drug as an EUA for covid. We are not there yet, but the FDA is interested in exactly the type of solution Abivertinib could offer: a new drug, that isn't a totally new drug, just an improvement on something that has already been tested. A EUA request can happen in the next couple months.
And 2nd: this development opened the doors for Abivertinib to also eventually be used for treatment of certain types of leukemia and lymphomas. Larger market options.
Bottom line: by all current indications Abivertinib is a better option than any other 3rd generation EGFR inhibitor and the best hope for an inhibitor that works against covid.
For perspective: Targisson (the product) an approved 3rd generation drug which most resembles Abivertinib but by all standards seems to be less effective, is Astra-Zenaca's top selling drugs with sales of over 4 billion dollars per year.
This is just ONE of the drugs Sorrento (SRNE) has in it's pipeline. Just one. This stock is undervalued in a way that people just wouldn't imagine...
If you find this interesting/useful, let me know and I'll highlight some other stuff in their pipeline in a simple to understand way. Some of the stuff there is pretty amazing."
