Mind Medicine (MindMed) Inc (MNMD)

[DarthYoda]

This news should bode well for our LSD Neutralizer(LSD+Ketanserin)...

Psilocybin+Ketanserin...

"Psychedelic Trip May Not Be Necessary For Anti-Depressant Effects Of Magic Mushrooms"

The study authors then treated the animals with psilocybin, along with a substance called ketanserin, which blocks the 5-HT2A receptor and therefore prevents the drug from producing any psychedelic effects. Reporting their findings in the Proceedings of the National Academy of Sciences, the researchers explain that this did not dampen the anti-depressant efficacy of psilocybin, as evidence by the rodent’s renewed interest in both sugar water and female urine after treatment.

https://www.iflscience.com/brain/psychedelic-trip-may-not-be-necessary-for-antidepressant-effects-of-magic-mushrooms/

Here is the actual paper. Accepted on March 9, 2021, but looks like it will be officially published April 27...

"Harnessing psilocybin: antidepressant-like behavioral and synaptic actions of psilocybin are independent of 5-HT2R activation in mice":
April 27, 2021

Significance
Psychedelic compounds, such as psilocybin, have beneficial actions in several psychiatric diseases. They also produce strong alterations of consciousness, which may be a barrier to their widespread use. We found that psilocybin has fast-acting antidepressant-like properties in mice. Using multiple assays of hedonic behavior and an antagonist of prohallucinatory 5-HT2A receptors, we further suggest that altered perception may not be necessary for its therapeutic actions. We also showed that psilocybin strengthens connections between brain cells in regions important for processing rewards and emotions. These experiments suggest that it may be possible to retain the beneficial actions of psilocybin while minimizing the alterations in consciousness, thereby accelerating its use in the clinic.

https://www.pnas.org/content/118/17/e2022489118