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Re: Fumbler post# 154832

Thursday, 03/25/2021 5:48:52 PM

Thursday, March 25, 2021 5:48:52 PM

Post# of 233005

It's interesting you should bring up a GM-CSF mediator, like Lenzulimab, in this forum. You do know that CCR5 controls much of the downstream biology including GM-CSF, don't you? Leromlimab > Lenzulimab.


I realize that leronlimab might have some GM-CSF lowering qualities. It probably accounts for the small benefit that it showed in trials. But it's not going to be as effective at stopping GM-CSF as a GM-CSF inhibitor like HGEN's lenzilumab. GM-CSF inhibition is lenz's MoA.
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