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Sunday, March 14, 2021 7:39:53 PM
That being said, I am referring to "there are not as many events as expected" by Geert and the increase in enrollment to 928 because of that.
I am suggesting it is remotely plausible that the initial CRO enrolled patients with high survivability ( base of the tongue ) in error since those are to be excluded.
That would produce "fewer events than expected" up to the point where "hey, we better enroll more patients"
This could also explain some skew in the expectations in various spreadsheets.
"There should have been this many by this time according to SEER data..." but it is way, way, out of whack. And it is only superficially that it looks like "it must be due to effectiveness". If you look deeper, as a couple of us have now, there is certainly more to it than merely it works. Something else is afoot, some extra factor of survivability.
That's all I'm saying. It is one possible scenario, however remote.
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