As for prostate, I know AUTL will move AUTO7 into the clinic next year. It has most of the enhancement 'modules' as AUTO6NG*, but will also locally secrete IL-12, the CAR has been designed to have improved activity in an acidic TME, and is able to target PSMA+ cells that have greatly reduced antigen expression.
* A safety switch, dnSHP2 (blocks PD-1, CTLA-4, TIGIT, 2B4 and BTLA signaling), chimeric cytokine receptor (to improve expansion and persistence), and a dnTGFßRII receptor.
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