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Thursday, March 04, 2021 8:19:50 AM
The new formulation was described as a "physical" ADF, meaning it is a hard-shell that resists crushing and cannot be hydrated for a syringe. These are PEG-based formulations that do not contain naltrexone. This kind of hard-shell ADF could be used to make an ADF version of Adderall or any other CNS stimulant.
I know what many are thinking: "Hey, an inert hard shell, that sounds like something so simple that not even Nasrat could manage to screw it up." Not true at all. It was the PEG-based hard shell that was implicated in the Opana disaster. Turns out the molecular weight and cross-linking of the PEG molecules is quite finicky. Abusers very quickly figured out that with a few extra steps the ADF Opana was nicely injectable. The process required tools like steel wool that tended to be used over & over, which led to multiple clusters of viral outbreaks, including HIV and Hep C. Illicit injection of Opana has also been linked to an acquired lupus-like autoimmune condition in several people.
Combining the extended release formula and the PEG-based hard shell to form a safe and effective ADF is no slam dunk, especially for a company that failed in 2 tries to get FDA approval for a simple oxyIR bead.
Occam's razor: the simplest solution is most likely the right one.
Hanlon's razor: never attribute to malice that which is adequately explained by stupidity.
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