Relief Therapeutics Holding AG (RLFTF)

[changes_iv]

SEEMS MORE RESEARCH IS NEEDED——

Cystic fibrosis is a progressive, genetic disease that causes persistent lung infections and limits the ability to breathe over time.

https://www.cff.org/What-is-CF/About-Cystic-Fibrosis/

Because VIP was not completely absent, this evidence is insufficient to rule out VIP as the vasodilator transmitter. However, the CGRP and substance P innervation we observed could mean that release of one or both of these peptides was the mechanism of the fully developed active cutaneous vasodilation.

https://pubmed.ncbi.nlm.nih.gov/1706332/

Noncholinergic neurons contribute to innate airway defenses by releasing vasoactive intestinal peptides (VIP), which stimulates the submucosal glands to produce a bicarbonate-rich fluid containing mucins and antimicrobial factors. VIP elevates cAMP and activates cystic fibrosis transmembrane conductance regulator (CFTR) channels; however, its effects on surface expression have not been investigated.

https://www.researchgate.net/publication/51423838_Vasoactive_Intestinal_Peptide_Increases_Cystic_Fibrosis_Transmembrane_Conductance_Regulator_Levels_in_the_Apical_Membrane_of_Calu-3_Cells_through_a_Protein_Kinase_C-Dependent_Mechanism